Case presentation A 50-year-old woman is being treated with sertraline for major depressive disorder for more than two years. She has been suffering from weakness, cold intolerance, and constipation and has been experiencing weight gain for the past six months.

Physical examination Dry, coarse skin Bradycardia Hypothermia Swelling of the hands and feet   Which laboratory study, according to you, is most appropriate to diagnose her condition? (Answer is posted in the comment section below!) *This case is from the Editorial Team of Docplexus and is meant for educational purposes only.