Cystic Fibrosis (CF) is life-limiting autosomal recessive genetic disorder commonly seen in the US and UK. It is caused due to abnormal transport of chloride ions across the apical membranes of the epithelial cells in the lungs. CF affects the body’s mucus glands. The thick mucus causes clogging of the airways and traps the bacteria leading to infections, lung damage and also limiting the breathing ability.
Along with the respiratory system, it causes severe damage to the health leading to malnutrition and poor growth. Patients with CF lose an excessive amount of salt along with sweat. Medical problems associated with CF : Sinusitis Clubbing Pneumothorax Hemoptysis Cor pulmonale Abdominal pain and discomfort Rectal prolapse Male infertility Genetic Changes: CFTR is the gene which is responsible for the transport of chloride ions and is regulated by cyclic Adenosine Monophosphate (cAMP).…
