Diagnosis of Parkinson’s disease (PD) is mainly based on symptomatic features. However, early detection of PD remains a major challenge currently. A study published in Lancet Neurology evaluated the accuracy of α-synuclein seed amplification assay (αSyn-SAA) that can detect the buildup of a-synuclein plaques in PD patients and those who are at risk of the disease.
The study analyzed the CSF samples of 1,123 participants with PD , scans without evidence of dopaminergic deficit, non-manifesting carriers (GBA and LRRK2 mutations), and healthy individuals . The sensitivity of the assay for the different participant groups was as follows: 87.7% for patients with PD 98.6% for patients with sporadic PD with a common olfactory deficit αSyn-SAA produced positive results for 67.5% of patients with LRRK2 mutations 78.3% of patients with sporadic PD without olfactory deficit 86%% of the patients…
