The discovery of new SARS-CoV-2 mutations has raised several questions on the efficacy of the available vaccines. As a result, experts have said that effective antivirals are urgently needed to protect people from SARS-CoV-2 infection. Researchers have recommended that a combination of antivirals can be used against SARS-CoV-2, similar to the HIV-1 combination therapy. Acriflavine (ACF) is an efficient inhibitor of SARS-CoV-2, according to a recent study published in the journal Cell Chemical Biology.
The drug is a combination of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine) . ACF has been clinically tested. Although the drug is indicated to have several side effects, such as liver toxicity and DNA intercalation, no adverse effects were observed during the clinical studies. Many countries use…
