Some individuals who are otherwise healthy show a prolonged duration of neuromuscular blockade after a usual dose of succinylcholine. They possess atypical pseudocholinesterase enzyme which has reduced capacity to metabolize its substrate. Reduced rate of succinylcholine metabolism. A Low activity of pseudocholinesterase. In blood Low concentrations of Pseudo-cholinesterase. Its function is measured in terms of Dibucaine number (DN).
Types of pseudocholinesterase: ASE Response to Scoline Typical Normal Atypical heterogeneous Mild prolong Atypical homozygous Dibucaine no. 70-80 50-60 20-30 Greatly prolong Dibucaine is a local anesthetic which inhibits pseudocholinesterase. A normal enzyme is inhibited more effectively Dibucaine 70-80% as compared to an atypical enzyme. The percentage of inhibition of pseudocholinesterase is termed as Dibucaine number. It is directly related to…
