VITAMIN B12 DEFICIENCY AND ANESTHESIA Vitamin B12 and anesthesia: anesthetic with laughing gas uses up large amounts of B12 and can cause deficiency. Info on B12 deficiency following an operation   General and Local Anesthetic Require Vitamin B12 —  General and local anesthetic are essential for many operations and medical interventions. One of the most commonly used drugs used in anesthesia is a nitrous oxide (N2O), otherwise known as “laughing gas”, however, this anesthetic, unfortunately, has the side effect of depleting up to 60 percent of the vitamin B12 stored in the body.

No matter how necessary it may be, nitrous oxide is a poison for the body that must be rendered harmless. This can be done by allowing the substance to react with methylcobalamin or reduced cobalamin. Through this, laughing gas breaks down into the water and non-reactive nitrogen, and the central cobalt atom…