Aplasia cutis congenita is a heterogenous group of rare hereditary disorders characterized by the absence of a portion of skin in a localized or widespread area at birth. It was first described by Cordon in 1767. Aplasia cutis congenita commonly affects the scalp; however, it can affect any part of the body, including the trunk and limbs. It may manifest as localized, solitary lesions or sometimes as diffused, multiple lesions. In 1986, Frieden et al.
classified aplasia cutis congenita into nine groups, based on the number and location of the lesions and the presence or absence of associated malformations. Adams Oliver syndrome (AOS) is an extremely rare genetic disorder that may be present at birth. It is aplasia cutis congenita with terminal transverse limb defects and is characterized by abnormalities in skin development, defects of the scalp, and malformations of the limbs. Most…
