Assessing Renal Function Using Cockcroft-gault And Modification Of Diet In Renal Disease Equations In Healthy South Indian Males – A Pilot Study

Objective: To compare the estimated GFR (eGFR) calculated by CG and MDRD formulae and to study the correlation between body mass index (BMI) and eGFR in healthy South Indian men. Material & Methods: Healthy male volunteers were enrolled. eGFR was estimated by CG and MDRD equation and cate-gorized as normal, mild, moderate, severe renal impairment and renal failure. Estimated clearance by these two methods was compared using paired student’s t test. Correlations were performed with pearson’s correlation test.

Results: A total of 491 subjects were enrolled. Mean (±SD) eGFR was 91.05 (± 15.04) and 86.43 (± 13.61) by CG and MDRD equations respectively; this difference though statistically significant (p=0.01), was clinically insignificant. A reduced renal function (<90ml/min) was found in 50.9% and 63.1% of population by CG and MDRD formulae respec-tively. BMI positively correlated with…