With the increasing clinical adoption of resin-based and bioceramic pulp capping materials , understanding their interaction with dental stem cells has become critical. An in vitro evaluation using stem cells from human exfoliated deciduous teeth (SHEDs) compared the cytotoxicity, genotoxicity, and migration potential of resin-based bioactive materials (NeoLiner LC and TheraCal PT), a bioceramic cement (BioC Repair), and conventional materials such as Biodentine and mineral trioxide aggregate (MTA). Select dilutions of Biodentine, TheraCal PT, and NeoLiner LC demonstrated enhanced cell viability, while resin-based materials and Bio C Repair showed substantially higher DNA damage indices than MTA.
Notably, Bio C Repair exhibited superior cell migration capacity, suggesting regenerative potential despite its genotoxic profile. These findings indicate that although newer bioactive…
