Among distant metastases, bone is commonly involved in patients with breast cancer. Evidence of bone metastases is often a signal for protracted illness. Severe complications undermine the quality of life in patients with metastatic bone disease. The available treatment modalities have enabled a better survival after diagnosis of breast cancer. Successful treatment also depends on the control of metastases.
Pathology of bone metastases in breast cancer An uncoupling of osteoclastic activity occurs due to a complex interaction of the tumor cells, products of malignant cells and bone microenvironment. The disproportionate osteoclastic activity manifests as lytic lesions of the skeletal framework. Osteolytic lesions due to bone metastases give rise to complications which are called as skeletal related events (SRE). Risk factors for bone metastases include The incidence of bone metastases…
