Designated as of keratoconus is unknown however association between keratoglobus and disorders like Ehler Danlos type 6 Marfans syndrome. Blue sclera syndrome indicate that etiology may result from defect in collagen synthesis there are no risk factors  however identified unlike other non-inflammatory corneal ectasias such as keratoconus eye rubbing has not been designated as risk factors  we have 2 forms of keratoglobus   Cong from is from birth and is associated with Ehlers Danlos type 6 Congenital Leber's amaurosis Blue sclera syndrome Acquired form is associated with Keratoconus V K conjunctivitis Dysthyroid ophthalmopathy Chronic marginal blepharitis Share your opinion.