Apical periodontitis (AP) is known to raise systemic inflammation and has been linked to various cardiometabolic disorders. However, whether endodontic treatment can meaningfully improve systemic metabolic profiles has remained uncertain. To address this, a study evaluated how successful endodontic treatment influences metabolic syndrome (MetS) indicators, inflammatory biomarkers, and blood and intracanal microbiomes in 65 patients with AP. Over the two-year follow-up, 24 metabolites showed significant postoperative changes.
Patients exhibited improvements in glucose and lipid metabolism, marked by reduced branched-chain amino acids at three months and lower glucose and pyruvate levels at two years. Short-term decreases in cholesterol, choline, and fatty acids, along with a steady increase in tryptophan, further indicated a decline in systemic inflammatory burden. These metabolic shifts…
