A recent systematic review of randomized trials finds that structured Mediterranean and low-carbohydrate nutrition programs , often combined with exercise, can blunt androgen-deprivation–related weight gain, metabolic syndrome, and cardiometabolic risk in men on hormone therapy for prostate cancer. Across 16 trials , lifestyle interventions were feasible, generally safe, and improved labs, body composition, and quality of life, though benefits often waned without ongoing support; adjuncts like creatine modestly favored lean mass, and multidisciplinary or community-based models enhanced adherence and durability.
The evidence base still lacks trials of newer anti-metabolic agents such as GLP‑1 receptor agonists, underscoring the need for longer, larger studies that integrate diet, weight management, and pharmacologic strategies into survivorship care. Read the full review to rethink…
