Age, female sex, ionizing radiation , neurofibromatosis type 2, and use of high-dose progestogens, including chlormadinone, cyproterone, and nomegestrol are known risk factors for intracranial meningioma. However, various other progestogens are commonly used for different purposes. An observational study has investigated whether other progestogens increase the risk of meningioma in 18,061 women who had intracranial surgery for meningioma (mean age – 57.6 years) compared to 90,305 controls.
Prolonged (≥1 year) use of medrogestone (odds ratio [OR] – 4.08), medroxyprogesterone acetate (OR – 5.62), and promegestone (OR – 2.74) were associated with increased risk of meningioma. In contrast, no such association was found in the use of progesterone (OR – 0.88), dydrogesterone (0.89), or levonorgestrel (OR – 0.94) intrauterine systems. Although further studies are required to understand this…
