Naproxen and ibuprofen at moderate dosages are associated with significantly more major NSAID toxicity events than celecoxib among older adults with arthritis and established coronary artery disease or risk factors, says a study recently published in American Journal Of Medicine. NSAID are associated with toxicities in older patients and hence, precise information regarding the relative safety of NSAIDs is necessary for doctors. Older patients who require chronic NSAIDs have multiple comorbidities, placing them at relatively high risk of NSAIDs toxicities.
Therefore, precise information regarding the relative safety of NSAIDs among common subgroups, such as those defined by age, sex, underlying arthritis, NSAID dosage, known cardiovascular disease, diabetes, aspirin use or tobacco use is important. The PRECISION trial compared the relative cardiovascular safety of celecoxib, naproxen…
