Tuberculous meningitis (TBM) is still one of the common infections of central nervous system (CNS). Despite modern antituberculosis chemotherapy, 20% to 50% of patients still die, and many of the survivors have significant neurological deficits. Death from TBM is strongly associated with delays in diagnosis and treatment.

In the light of above, what are the significant diagnostic challenges in the management of tuberculous meningitis?