In a 36-year cohort of nearly 2,000 individuals followed from school age into their late 40s, investigators mapped BMI transitions from childhood to adulthood against cardiovascular-kidney-metabolic (CKM) syndrome stages in midlife. Adults who moved from normal BMI in childhood to overweight in adulthood had markedly higher odds of intermediate and advanced CKM stages, along with more diastolic dysfunction, subclinical kidney injury, albuminuria, and metabolic abnormalities than peers who remained normal weight. Crucially, individuals who were overweight in childhood but returned to normal BMI by adulthood showed CKM risks comparable to those with persistently normal BMI.
The findings strongly support aggressive early-life and young-adult interventions to normalize BMI as a means to “reset” long-term CKM risk. To read more click here ##Reference## Wei Y, Zhang T, Li X, et al. Transition…
