A 54-year-old man was presented to the ED with a 3-week history of cognitive deterioration and functional decline. He was disoriented, and inattentive. Examination Neurologic examination revealed horizontal gaze-evoked nystagmus, hyperreflexia on the left side, and ataxia. MRI was acquired. T2 weighted (Panel A); Diffusion-weighted imaging (Panel B).
Electroencephalography indicated lateralized periodic discharges in the right hemisphere without evidence of seizures. CSF was positive for 14-3-3 and tau proteins. What is the most likely diagnosis? *This case is from Docplexus editorial team for educative purpose only. Source: NEJM Stay Connected, the answer will be posted in the next 48h!
