Optimizing IVF Outcomes: Does When You Start Dexamethasone Matter Dexamethasone is often used as an adjuvant in IVF, but its optimal timing during controlled ovarian stimulation remains unclear. This retrospective cohort study of 644 cycles evaluated how initiation timing influences ovarian response, embryo development, and live birth outcomes. The findings revealed that mid- and late-cycle dexamethasone were associated with a higher number of usable embryos , indicating improved ovarian response.
However, when it came to clinical outcomes, e arly- and mid-follicular initiation showed significantly higher live birth rates compared to no dexamethasone, while late initiation offered no clear benefit. These results remained consistent even after adjusted and propensity-weighted analyses. Interestingly, improved embryo yield did not fully explain the higher live birth rates, suggesting…
