Saliva is a unique biologic dynamic fluid that has varying spectrum of proteins, polypeptides, nucleic acids, electrolytes, and hormones. It is an exocrine secretion of the salivary glands which is hypotonic in nature with a pH of 7.2–7.4 [1]. The diagnostic potential of saliva is reflected by the presence of multiple biomarkers which appears at a concentration much lesser than blood and still serves as a mirror reflecting the body’s health and wellbeing [2].
Saliva is a product of three major salivary glands: parotid, submandibular, and sublingual with added secretions from minor salivary gland [3]. The variety of enzymes, hormones, antibodies, antimicrobial constituents, and growth factors are incorporated into the saliva from the blood through the transcellular and paracellular routes [4]. Hence saliva bears a functional equivalent with the serum and reflects the physiological state…
