A prospective study of 232 children with early-onset high myopia (eoHM) shows that more than half present with significant ocular or systemic comorbidities —highlighting that eoHM is often a marker of deeper pathology rather than an isolated refractive condition. Children demonstrated severe refractive errors (mean SE −9.24 D), elongated axial length, and reduced BCVA, with lens dislocation (18.9%) and inherited retinal degeneration (11.5%) emerging as the most common associations. Whole-exome sequencing identified pathogenic variants in all evaluated cases, predominantly involving retinal genes, underscoring the genetic and multisystem implications of eoHM. To read more; Click here ##Reference## Ding Y, Xie F, Zhang J, Jiang M, Wang T, Wan X.
Clinical features of early-onset high myopia: attention to comorbidities. BMC Ophthalmology. 2025.##
