Synopsis A recent clinical study demonstrates that sitagliptin decreases the progression of carotid Intima-Media thickness (IMT) in insulin-treated patients with Type 2 Diabetes Mellitus (T2DM), free of cardiovascular diseases (CVD). This week's ' MED FACT ' discusses a clinical trial from Diabetes care , “Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients with Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial”. March 2016, Volume 39, Issue 3, 455-464.
Authors : Mita T; Katakami N; Shiraiwa T; Yoshii H; Onuma T; Kuribayashi N; Osonoi T; Kaneto H; Kosugi K; Umayahara Y; Yamamoto T. Key Takeaways Sitagliptin in addition with insulin, significantly reduced the IMT of carotid arteries as compared to other conventional treatments. Objective: To study the effects Of…
