Highlights ON101 exhibited better healing efficacy than standard absorbent dressing alone in the treatment of diabetic foot ulcers (DFUs). Topical application of ON101 exhibited consistent efficacy in wound healing among all patients, including those having high-risk factors related to DFUs. This Journal Watch discusses the study “Effect of a Novel Macrophage-regulating Drug on Wound Healing in Patients With Diabetic Foot Ulcers A Randomized Clinical Trial” published in JAMA Network Open, 2021 .
What was the need for the study? There is a significant need for new and effective interventions beyond the current clinical practices of local wound care to tackle the life-debilitating and even life-threatening conditions of diabetic foot ulcers. Diabetic wounds display prolonged proinflammatory M1 macrophage polarization and impaired transition to pro-regenerative M2 macrophages as opposed…
