Functional endoscopic sinus surgery (FESS) is widely established as an effective intervention for chronic rhinosinusitis with nasal polyps (CRSwNP), yet outcome variability remains a critical challenge. In a cohort of 153 patients, postoperative health-related quality of life (HRQoL) improved significantly across global, physical, and social domains, with the greatest benefit observed in those reporting the poorest preoperative HRQoL scores. Interestingly, among a wide spectrum of clinical and demographic variables, only the preoperative HRQoL score consistently predicted postoperative improvement.
In contrast, eosinophilia stood out as the sole independent predictor of revision surgery risk, highlighting the biological underpinnings of disease persistence despite surgical intervention. These findings underscore the need for refined patient stratification in surgical decision-making. …
