Sperm DNA fragmentation (SDF) is the clinical term used to denote any abnormality in the genetic make-up of sperm DNA. DNA fragmentation is one of the causes of male subfertility and accounts for in vitro fertilization (IVF) failures and miscarriages. The SDF test analyses the sperm DNA integrity that is used to identify the risk of subfertility in men and also provides the basis for the treatment. Antioxidant therapy is one of the promising treatments for SDF.
A combination of several supplements like L-carnitine, vitamin C, vitamin E, vitamin B9 and B12, zinc, selenium, and coenzyme Q10 are used as antioxidants for treating DNA fragmentation. Though the existing antioxidant supplements have shown promising results, these anti-oxidants may lead to the decondensation of nuclear DNA. Thus, the selection of an appropriate combination and therapeutic regimen is of utmost importance for…
