Central Nervous System (CNS) are rare neoplasms with considerable heterogeneity and variation. A majority of the data available has emerged from the west. This article gives an overview of the treatment options and patient responses documented from Indian population. Tumors of the central nervous system (CNS) are rare and heterogeneous in nature.

Among CNS tumors, glioblastoma multiforme (GBM) are the most common type of tumors. Age, history, site in the CNS amounts to variation, whereas the geographical, genetic, phenotypic differences in the population further amount to the representation, incidence, behavior and response to the treatment of cancer. In this context, this article gives an overview of the clinical data available from the oncology centers in India. Molecular Pathways Responsible For GBM The concept of different genetic pathways responsible for GMB includes primary GBM…