This in vitro study investigated the effect of green-synthesized titanium dioxide (TiO₂) nanoparticles —derived from Azadirachta indica (neem) extract—on the mechanical stability of polymethyl methacrylate (PMMA) denture base resin exposed to denture cleansers. Among experimental groups, TiO₂ incorporation significantly enhanced flexural strength, hardness, and resistance to surface degradation , with PT1 ( 1.5% wt ) showing the highest flexural strength and PT3 ( 5% wt ) demonstrating superior hardness. SEM, FTIR, and EDAX confirmed nanoparticle morphology and composition.

Importantly, exposure to cleansers did not adversely affect surface roughness, indicating strong durability. These findings highlight the potential of eco-friendly, neem-based nanotechnology to extend denture longevity, reduce repair frequency, and improve prosthetic performance in clinical practice. To read the full…