Reported among less than 1 in 10,00,000 patients, Scott syndrome is an extremely rare congenital bleeding disorder that is due to defective platelet phospholipid membrane support and characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications. This article reviews the etiology, diagnosis, and little but available management strategies for Scott syndrome. Scott syndrome is a rare inherited hemorrhagic disorder linked to the inability of procoagulant phosphatidylserine (PS) to translocate to the outer phospholipid membrane leading to reduced support capacity of the tenase and prothrombinase complexes and, thus, reduced overall thrombin generation.
It is not associated with any congenital disorders. Platelets in patients with Scott syndrome have normal adhesion, aggregation, and secretion but they poorly support the coagulation…
