A 68-year-old woman, a known case of Hepatitis B virus (HBV) carrier, was admitted to the hospital with abdominal distension without any reports of jaundice or fever. Medical history No genetic history of HBV More than ten years of HBV history without antiviral treatment Investigations and corresponding observations Techniques Observations Preoperative computed tomography (CT) i)Huge Hepatocellular Carcinoma (HCC; tumor size-15 cm; BCLC stage B) in the right lobe of the liver ii)Suspected diaphragm invasion,  tumor thrombus in the right branch of the portal vein, and tumor pressure of the portal vein iii)No reports of intrahepatic metastasis or lymph node metastasis (Figure 1), the middle hepatic vein pressed by the tumor Ultrasonography (USG) No portal vein tumor thrombus Preoperative biochemical examinations (i) AFP: 8760 ng/ml (extremely high) (ii) HBV-DNA 3.43 * 103 copies/ml…