The role of elevated lipoprotein(a) as a long-term predictor of cardiovascular disease remains debated, particularly in primary prevention. To address this uncertainty, investigators assessed the association between baseline lipoprotein(a) levels and cardiovascular risk over nearly three decades in 27,748 initially healthy women with a mean age of 53 years. During a median follow-up of almost 28 years, lipoprotein(a) concentrations above 30 mg/dL, corresponding to the 75th percentile, were associated with a higher 30-year risk of major cardiovascular events (MACE) and coronary heart disease (CHD).
In contrast, only very high lipoprotein(a) levels above 120 mg/dL, or the 99th percentile, were associated with increased risk of ischemic stroke and cardiovascular death . Compared with women with lipoprotein(a) levels below 10 mg/dL, those with levels above 120 mg/dL had…
