Huntington’s disease or Huntington’s chorea is an inherited progressive neurodegenerative disorder characterized by choreiform movements, psychiatric problems, and dementia. Although the pathophysiology of Huntington’s is not fully understood, it is believed to be related to the toxicity of the mutant huntingtin protein. There is no cure or disease-modifying treatment available for this condition. The treatment is focused on symptom management and supportive care to optimize the quality of life.
These aspects are covered in detail in this article. Huntington’s disease is caused by a trinucleotide (CAG) expansion in the Huntington gene on the chromosome 4p and inherited in an autosomal-dominant pattern. Management of Chorea Chorea may be aggravated by various factors such as stress, anxiety, and depression. It is important to identify and treat the underlying mood and anxiety disorders.…
