IgA nephropathy (IgAN), also known as Berger's disease, is a chronic glomerulonephritis characterized by the deposition of IgA immune complexes in the mesangium, leading to glomerular inflammation and progressive renal damage. It often presents with episodic gross hematuria, microscopic hematuria, or proteinuria, typically following mucosal infections such as upper respiratory tract infections. Histopathologic diagnosis of IgAN is confirmed via kidney biopsy, which shows IgA-dominant immune deposits with mesangial proliferation on immunofluorescence microscopy.
Management of IgAN focuses on controlling blood pressure, proteinuria, and inflammation, with immunosuppressive therapy reserved for progressive or severe cases. Monitoring renal function over time is critical, as 20-40% of patients progress to end-stage renal disease. Join us in celebrating our 11 th Anniversary with an…
