Booster COVID-19 vaccines can help in the continuous protection against severe infection; however, the immune response can vary across individuals. Moreover, the persistence of memory B and T cell responses have not yet been extensively investigated. A study published in the Journal of Immunology has assessed the persistence of memory B and T cell responses after the mRNA COVID-19 vaccine , along with their cross-reactivity to the Omicron variant, and highlighted the following findings.
The level of memory B cells increased, but that of neutralizing antibodies and memory T cells decreased in months after two primary doses of BNT162b2 vaccine . Booster dose increased memory B cells but only recovered neutralizing antibodies and memory T cells to the levels achieved after the second vaccine dose. Memory T cells exhibited cross-reactivity against the Omicron variant receptor binding domain…
