Hyperthyroidism in pregnancy: Pregnant woman in hyperthyroidism are usually treated with propylthiouracil as carbimazole may cause foetal abnormalities. Whichever thiouracil is used, it should be given in smallest dose. Various combinations of the terms antithyroid drugs, thionamides carbimazole, methimazole and propylthiouracil. Pregnancy side effects: Agranulocytosis, birth defects, congenital malformation, embryopathy, aplasia cutis, Hepatotoxicity, hepatic failure maternal and fetal are observed.
To reduce risk PTU in the first trimester and CBZ/ MMI in the later trimester causes minimal risk. Thiourea given in smaller dose permitting mild hyperthyroidism is well tolerated by a pregnant woman. The other carbimazole and propylthiouracil cross placental barrier, induce fetal hypothyroidism, TSH hyper secretion and goitre. Administratoration of thyroid hormones doesn't prevent…
