An in vitro study evaluated injectable platelet-rich fibrin (i-PRF) as a root surface biomodification (RSB) adjunct following 24% EDTA treatment on dentin discs. i-PRF applied for 3–5 min promoted spindle-shaped gingival fibroblast morphology , enhanced actin filament organization , and increased intracellular and extracellular alkaline phosphatase (ALP) expression. No significant differences in cell viability were observed between i-PRF and enamel matrix derivative (EMD) controls. The results suggest that i-PRF application time is critical and that i-PRF + EDTA may support future in vivo and clinical periodontal regenerative strategies.
To read more; Click here Could i-PRF become a standard adjunct for periodontal tissue regeneration? ##Reference## Altay, C., Güngörmüş, M., Bal, C. et al. Effects of injectable platelet-rich fibrin (i-PRF) application as root surface biomodification on…
