bilirubin is a potentially toxic catabolic product of heme metabolism,when its level reached upto 3mgs/dl we termed it clinical jaundice that first appear on scelera and observed as a sign its not a disease but indicative of many hidden diseases. Bilirubin formed by breakdown of heme that present in haemoglobin, daily production of bilirubin is 250 to 400 grams in a day, 85% of it come from heme and rest from precursors of rbc that destroy in bone marrow.
RBC's are generated in bonemarrow and destroyed in spleen, this heme turned into unconjugated bilirubin that taken up by hepatocytes in liver and cojugated with glucoronic acid as conjugated bilirubin, unconjugated bilirubin is not soluble in water but conjugated is soluble in water. This conjugated bilirubin excreated through bile in doodenum,this is not absorbed by gut for entero hepatic circulation like bile salts but in colon by…
