Hematophagous animals including leeches have been known to possess biologically active compounds in their secretions, especially in their saliva. Their saliva has over 100 bioactive substances that are very beneficial. One such component is hirudin, which acts as an anticoagulation agent. Calin is another component that also inhibits blood coagulation. A component that dissolves fibrin clots as well as inhibits the formation of thrombus is the destabilase.
Leech saliva also contains a Factor Xa inhibitor, and this compound restrains the coagulating effect of the coagulation Factor Xa. It also has hyaluronidase that enhances the viscosity of the interstitial fluid. For vasodilating effect, it has acetylcholine and histamine-like substances as well as carboxypeptidase A inhibitors. These three can increase blood flow by dilating constricted vessels. Leeching was used to treat patients…
