L- Ornithine - L-aspartate (LOLA), the salt of the natural amino acids ornithine and aspartate acts through the mechanism of substrate activation to detoxify ammonia. L- Ornithine acts on the urea cycle. It acts as an activator of Ornithine Carbamyl transferase and Carbamyl Phosphate Synthetase. It acts as a substrate for urea Genesis. Thus it eliminates ammonia from the blood. L- Aspartate acts on Tricarboxylic Citric Acid Cycle.
It acts as a stimulus for hepatic glutamine synthesis in the perivenous scavenger cells which may be defective in acute and chronic liver disease. The inactive cells are activated and new cells are generated. Thus, the energy utilisation in the damaged liver is improved. In the literature, it is researched for hepatic encephalopathy in Europe and also the USA. In our hospital, this drug is used as IV infusion for hepatitis and five days course especially in…
