Juvenile polyposis syndrome (JPS) is an autosomal dominant condition characterized by multiple hamartomatous polyps throughout the gastrointestinal tract. Individuals with JPS are at increased risk for colorectal and gastric cancer. The hamartomatous polyposis syndromes constitute a group of diseases in which manifestations differ slightly and only molecular diagnostics gives the possibility of verifying the clinical diagnosis. The JPS belongs to the group of hamartomatous polyposes.
The disease is characterized by heterogeneity with regard to age and symptom intensity observed among members of one family. It can be assumed that, apart from inheriting a mutation in one of the predisposition genes, a modifying impact of other genetic factors is also present, although they have not been identified so far. Disease characterization JPS is a genetically conditioned predisposition to the…
