Treatment of peptic ulcer disease that invoves duodenal bulb and prepyloric ulcers continues evolve because of recent advances in pharmacology,bacteriology and operative techniques. the life time prevalance of peptic ulcer disease is 10% and chances of perforation around 5%,in western world and its more in 7th decade of life and with equal incidence in male and females but in asian countries its more common in younger patients and more in males. discovery of role of helicobactor pylori in pathogenesis changed the entire management algorthm for perforated peptic ulcer and ppis,laproscopic closure revolunised the management. causes of perforation in peptic ulcer disease 1. h.pylori its involve in 70 to 90% cases of all perforated cases.
2. non steroidal anti inflamatory drugs 3. zollinger ellison syndrome diagnosis.. 1. clinical presentation sudden onset of epigestric pain then rapidly…
