Membranous glomerulopathy, also known as membranous nephropathy, is a nephrotic syndrome characterized by massive proteinuria (>3.5 g/day). The chief etiological factor is still unclear, but a majority of the cases are autoimmune. Autoantibodies against phospholipase A2 receptor (PLA2R) antigen, neural epidermal growth factor-like 1 (NELL) antigen, thrombospondin (THSD7A), neutral endopeptidase (NEP), and exostosin (EXT1/EXT2) have been identified. The affected individuals demonstrate peripheral edema, hypertension, frothy urine, and thromboembolic phenomena.
Laboratory investigations of patients show hypoalbuminemia, dyslipidemia, and evidence of acute kidney injury with elevated serum creatinine. The early diagnosis and prompt management of membranous glomerulopathy are essential to prevent extensive kidney damage and kidney failure. Take this short quiz and test your knowledge of…
