Sleeve Gastrectomy helps only in 1 way in controlling Type 2 Diabetes. That is negative calorie balance. But Mini Gastric bypass helps in 2 ways in controlling type 2 diabetes. First, surgically induced direct delivery of nutrients to the small intestine will increase the GLP-1 response to a meal and enhance the insulin response.
Second, induction of sudden negative calorie balance by any means in type 2 diabetes normalizes plasma glucose levels within days, and this is the predominant mechanism underlying the early metabolic changes after bariatric surgery. It remains to be established what proportion of the enhanced meal-related insulin secretion is dependent on a change in incretin secretion and also what difference on long-term β-cell function results from surgically induced increased GLP-1 secretion. It would be of considerable practical utility to identify in advance individuals…
