Myasthenia Gravis is an autoimmune disease of the motor end plate. It causes a functional a functional decrease in acetylcholine receptors of the neuromuscular junction. Symptoms & signs are characterized by periods of exacerbation and remission. Clinical Features: 1 Ptosis and diplopia are common symptoms in the initial stage. 2 The weakness of most commonly used muscles, pharyngeal & laryngeal muscles, dysphasia, fascia weakness with chewing & speaking asymmetrical skeletal muscle weakness. 3.
May be associated with thymus tumors, cardiomyopathy, rheumatoid arthritis, systemic lupus erythatosis & thyroid disorders. 4 Short-acting anticholinesterase drugs can transiently increase the strength of the muscles. 5. Electromyography & nerve conduction studies and elevation acetylcholine receptor antibody assay are helpful to confirm the disease. Management: Anticholinesterase drugs:…
