Fungi are a leading cause of infections and deaths worldwide. Current anti-fungal drugs have started being ineffective due to the emergence of drug-resistant fungi. Novel antifungal drugs are hence needed to combat this issue. This article summarizes recently found drug molecules to treat resistant fungi. There are about 5 million fungal species, out of which, about 300 are pathogenic. However, only about 20-30 species cause frequent infections in humans.
The most common pathogens reported are Candida, Aspergillus, Pneumocystis, and Cryptococcus species. Per year, these fungal species cause at least 1.4 million deaths worldwide. There are many effective anti-fungal drugs available currently which are broadly classified into three classes depending on their drug targets. Classes of currently used anti-fungal drugs are: 1. Triazoles (inhibit ergosterol biosynthesis) 2. Polyenes (mainly…
