Retinopathy is one of the major manifestations of diabetes which results from microvascular permeability. Therefore, understanding the molecular mechanism behind it is important for its treatment. In this regard, a recent study has identified a molecule Arf6 in the VEGF signaling pathway which plays a critical role in diabetic retinopathy. Diabetic retinopathy is the most common cause of impaired vision or loss of vision among people with diabetes.
At the biochemical level, the VEGF (vascular endothelial growth factor) signaling pathway plays an essential role in the pathogenesis of diabetic retinopathy. Some downstream effects of this signaling pathways include endothelial cell proliferation, migration, and barrier permeability. Current treatment approach: Antibodies specific to VEGF pathway (e.g. bevacizumab) did have some success in treating diabetic retinopathy but patients often…
