Instead of trying to make the body more sensitive to insulin, is it possible to treat type 2 diabetes by slowing the production of glucose in the liver? A new study, led by Washington University School of Medicine in St. Louis suggests it is. Working with mice, the team found that shutting down a liver protein that controls glucose production led to lower levels of blood sugar. The finding could lead to more effective treatments for type 2 diabetes, says study leader Brian N.
Finck, associate professor of medicine. One drug that the researchers experimented with in their study may have such an effect - the investigational drug MSDC-0602. According to the manufacturer - who describe MSDC-0602 as an insulin sensitizer - the drug is currently undergoing trials as a treatment for type 2 diabetes. Blocking pyruvate transport cut glucose production in the liver of mice. Previous research had…
