Empyema is defined as pus in the pleural space. Typically it is a complication of pneumonia but can arise due to other conditions like trauma, esophageal rupture and as a post-surgical complication. Late diagnosis and onset of appropriate therapy contribute to increased morbidity and higher hospitalization cost.
Few previous studies suggested that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during community-acquired pneumonia may be associated with an increased risk of empyema, but was not validated by any study to exclude the possible protopathic bias. This case-control study investigates children’s risk factors for empyema after acute viral infection and determines whether some viruses, use of NSAIDs or both were associated. The Study Cases and controls were enrolled for a source population of children 3-15 years of age with acute viral infections between 2006 and 2009…
