Proton pump inhibitors (PPI) are medications that are ubiquitous in the medical field, this class of medications has been available for use for 25 years and this acid reducing agent has supplanted the use of histamine2receptor antagonist like ranitidine. proton pump inhibitors are most sold the drug and in PPIs omeprazole is first one, omeprazole discovered in 1979 and first marked in 1989. other members of PPIs are lansoprazole, esomeprazole, pantoprazole, rabeprazole and illaprazole.
Mode of action: Proton pump inhibitors act by irreversibly blocking hydrogen/potassium adenosine triphosphatase enzyme (proton pump), this proton pump acts on the terminal stage of acid secretion of the gastric parietal cell and reduces the basal and stimulated acid secretion and this reduction may be up to 99%. as proton pump proteins rendered nonfunctional and can be replaced by new copies. effect of…
