Type 1 and type 2 diabetes in the setting of high blood pressure is associated with the early development of target-organ damage, including cardiovascular and cerebrovascular disease and progressive renal insufficiency. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of developing diabetes than normotensives. The superimposition of hypertension on diabetes further aggravates microvascular and macrovascular complications via arteriolar and capillary damage in retinal, renal, coronary, cerebral, and peripheral vascular regions, accelerating the progression to targetβorgan failure.
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