Painful Diabetic Neuropathy (PDN) is a serious chronic neurological complication occurring in 50% of diabetes patients. Management approach includes a tight glucose control, foot care and pharmacological treatment for pain. This article discusses recommendations for the pharmacological treatment of PDN. Patients with PDN suffer from wide-ranging symptoms including numbness or reduced ability to feel pain or temperature changes, tingling or burning sensations and sharp pains or cramps.
Presently, pregabalin, tapentadol, and duloxetine are the only FDA-approved medication for the treatment of PDN. Pharmacologic treatment of PDN The AAN has recommended Pregabalin as first-line therapy. Gabapentin, duloxetine, amitriptyline, venlafaxine, opioids (morphine sulfate, tramadol, and oxycodone controlled-release), valproate and capsaicin are considered as the second-line therapies.…
